Injury Mechanism in Liver Transplantation and its Protective Measures - Abstract
This paper will explore mainly donated by brain dead liver donors (DBD). Brain death could induce much physiological and metabolic change in tissues, which is associated with hemodynamic instability and the increase of inflammatory mediators. Injury of donor liver mainly includes the injury before liver procurement, cold preservation injury, and ischemia-reperfusion injury. Liver preservation, immunosuppressant, and transplant operation are three key technologies for liver transplantation. Benefited from the development and application of new immunosuppressants and modern surgical techniques in the past 20 years, great progress in liver transplantation has been achieved in China. The purpose of this paper is to summarize the research progress in liver transplantation including the mechanism of liver injury in transplantation and its protective measurements.