Mechanisms of Extra Low Frequency Electromagnetic Field (ELF-EMF) on Human Bone Marrow Stem or Stromal Cell (hBM-MSC) Differentiation - Abstract
The differentiation of human Bone-Marrow Mesenchymal Stem/Stromal Cells (hBM-MSCs) is dependent on exposure to biophysical and biochemical stimuli that favor early and rapid activation of the in vivo tissue repair process [1]. Exposure to exogenous stimuli such as an electromagnetic field (EMF) can promote differentiation of hBM-MSCs via ion dynamics and small signaling molecules. The plasma membrane is often considered to be the main target for EMF signals, and most results point to an effect on the rate of ion or ligand binding due to a receptor site acting as a modulator of signaling cascades.