Tyrosine O Sulfation: An Overview - Abstract
Tyrosine O sulfation is a post translational modification (PTM) originally discovered by Bettelheim in 1954 in the bovine protein fibrinogen. Currently, this PTM is found only in secreted and transmembrane proteins of higher eukaryotes. This article gives an overview of experimental tools to study tyrosine O sulfation and also describes the biological function of this PTM.