Background: Burn is one of the most devastating traumas that someone can encounter in their life. Burn wound sepsis is still the leading cause of death in burned patients. Appropriate knowledge of causative pathogen in burn sepsis is important for successful patient management and for reduction of the incidence of antibiotic resistance Patients and methods: A retrospective study conducted between 2010 to 2017 at burn specialty hospital in Baghdad. A total of 320 blood culture samples were obtained from patients with sepsis or suspected to have sepsis. Patients age were ranging between 9 months – 70 years with mean total burn surface area 45.26% Results: The most common microorganisms were isolated from those patients who had sepsis or suspicion of sepsis were Klebsiella (48 cases) followed by pseudomonas (36 cases) Staphylococcus spp (26 cases) Enterococcus (8 cases) Acinetobacter (11 cases) E coli (11 cases) Candida (4 cases) Proteus (2 cases) and Salmonella, Streptococcus pneumonia, Monilia and Seriata one case for each. The commonly isolated organism was Klebsiella was sensitive to Imipenem followed by Amikacin Nitrofurantoin, Piperacillin, Ciprofloxacin, co-trimoxazole, Chloramphenicol, tetracycline, Azithromycin and Cefotaxime. Conclusion: Microbiologic Surveillance of burn patients with sepsis or suspicion of having sepsis for 8 years in our hospital (Burn Specialty hospital in Baghdad) had shown that the most common microorganism isolated from their blood culture was Klebsiella, Klebsiella was sensitive to Imipenem mainly according to sensitivity test by using disk diffusion method.