Association of Triglyceride Glucose Index Combined with Obesity Indicators with Left Ventricular Mass Index in Hypertensive Chinese Adults - Abstract
The left ventricular hypertrophy index (LVMI) is a vital metric for assessing LVH, a major complication of hypertension. The triglyceride-glucose (TyG) index
combined with obesity indicators is an emerging marker of insulin resistance (IR), positively associated with cardiovascular disease.In this cross-sectional analysis
of 4,551 Chinese adults with hypertension, we evaluated associations between TyG-derived indices (TyG-WC, TyG-BMI, and TyG-WHtR) and LVMI using
multivariable linear regression models adjusted for potential confounders, including age, sex, blood pressure, urea, among others. We performed subgroup
analyses, incorporating interaction tests, to evaluate the stability of results across demographic and clinical strata.Significant positive associations were found
between quartiles of TyG-BMI, TyG-WC, TyG-WHtR, and elevated LVMI. TyG-BMI showed the strongest dose-response relationship, with progressively
increasing ? coefficients (95% CI) across ascending quartiles (Q2: 3.163 [2.141–4.184], Q3: 4.754 [3.720–5.788], Q4: 8.055 [7.002–9.109]) compared
to Q1. Subgroup analyses showed consistent trends (all interaction P-values >0.05), suggesting homogeneous associations across demographic and clinical
subgroups. Our findings reveal robust associations between TyG-obesity indices (particularly TyG-BMI) and LVMI in hypertensive individuals with hypertension.
The consistency of these associations across clinical subgroups highlights the potential of TyG-obesity indices as composite biomarkers for monitoring cardiac
remodeling in hypertension management.