Epidemiological Aspects of Hepatitis B and Prognostic Factors of Cirrhosis in Patients with Chronic Hepatitis B in the Western Amazon - Abstract
Background and Aims: viral factors and host factors were associated with disease
progression of chronic hepatitis B (CHB) to cirrhosis. We studied 672 patients HBs
Ag+ followed at the Hepatitis Referral Centers of Rio Branco (AC), Brazil, from 2000
to 2009 to evaluate the clinical and epidemiological characteristics, and associated
factors the progression to cirrhosis.
Methods: Clinical and epidemiological features of 672 patients with CHB
cadastrado at Hepatitis Referral Centers of Rio Branco (AC), Brazil, from January
2000 to December 2009 were evaluated retrospectively. For the associated factors
the progression to cirrhosis, the dependent variable was cirrhosis and independent
variables were the exposures of interest. Unadjusted and adjusted odds ratios were
estimated by conditional logistic regression, and the confidence interval was set at
95% (95% IC).
Results: The average follow-up was 52.7 ± 12.8 months. A total of 8.5%
(57/672) of patients progressed to cirrhosis, with an incidence rate of 26.8/1000
person-year. The variables independently associated with progression to cirrhosis
were: male gender (OR = 2.2, 95% CI, 1.1 to 3.7); co-infection with HCV (OR = 4.6,
95% CI: 1.2 to 17.8); co-infection with HDV with HBe Ag+ (OR = 4.0 , 95% CI, 1.3 to
1.9); co-infection HDV with anti-HBe+ (OR = 7.1 , 95% CI, 1.2 to 17.8); and Gamma
GT serum levels > 2 ULN (OR = 2.7 , 95% CI, 1.3 to 5.4).
Conclusion: Male gender, concomitant infection with HCV, HDV and GGT serum
levels were independent progression factors to cirrhosis in patients with CHB.