Immunological and Genetic Pathways in the Pathogenesis of Inflammatory Bowel Disease - Abstract
Ulcerative colitis (UC), and Crohn disease (CD) a chronic inflammatory disease of the gastrointestinal tract, appears on the background of abnormal mucosal immune response and progresses with relapses [1]. UC is limited to the colon, starting from the rectum and spreading toward the proximal colon, and is characterized by ulcerations in the mucosa and submucosa [2,3]. Although UC can occur at any age, it is the most common in the age group of 15-30 years, followed by the age group of 50-70 years [2].