Objective: Quality of life is of great importance in chronic diseases such as ulcerative colitis. The aim of this study was to assess the correlation between quality of life and disease activity. Material and Method: In this study, we included patients who were admitted to the Celal Bayar University Gastroenterology Outpatient Clinic and diagnosed with Ulcerative Colitis. Demographic markers, such as age and sex, were collected from each of the patients. Smoking habits, alcohol consumption, and comorbidities were also asked. Quality of Life was assessed using the SF-36 scale. We used the MAYO scores to identify disease activity. Results: Our study results showed a negative correlation between the MAYO scores and SF-36 parameters, which was statistically significant. Conclusion: Based on these results, it was found that disease activity and quality of life were closely correlated in patients with ulcerative colitis, and the higher the disease activity, the lower the quality of life.