Severe Activity and Cytomegalovirus Colitis May Increase Risk of Venous Thromboembolism in Inflammatory Bowel Disease - Abstract
There is still a paucity of data on Venous Thromboembolism (VTE) in Asian
populations. We compared patients with VTE and IBD to matched IBD controls without
VTE. Of 4467 patients diagnosed with IBD, 26 patients with VTE were identified,
including 12 with Crohn’s Disease (CD) and 14 with Ulcerative Colitis (UC). The incidence
of VTE was 0.58%. The recent use of steroids (odds ratio [OR] = 7.00; 95% CI =
1.59–30.77; p = 0.010) and elevated C-reactive protein (CRP) (OR = 1.17; 95% CI
= 1.00–1.37; p = 0.046) were associated with an increased risk of developing VTE.
Each 1% rise in hematocrit decreased the risk of VTE by 14% (OR = 0.86; 95% CI =
0.77–0.97; p = 0.015). According to second analysis, CMV colitis is associated with an
increased risk of developing VTE (OR = 4.01; 95% CI = 1.49–10.78; p =0.006). The
incidence of VTE seems to be lower in Asian than in Western patients. Higher disease
activity is associated with an increased risk of developing VTE and CMV colitis may
also increase this risk. IBD patients with CMV colitis and higher disease activity may
require vigilant observation to diagnose VTE.