VDR Gene SNPs in Gastrointestinal Tumors - Abstract
GI tumors until now remain the major health problem in the world. The numerous risk factors are related to the development of GI tumors. Vitamin D is a multifunctional hormone with functions including immunomodulation or antioxidants to several intracellular like gene regulation, signal transduction, proliferation, and invasion of cancer cells. Among the risk factors, the genetic risk factor plays an important role in susceptibility to GI tumors. However, the association between genetic variants and GI tumors remains unclear. In particular, revealing the suitable genetic biomarkers for GI may provide a new opportunity to diagnose mentioned tumors. Specifically, To determine cancer susceptibility via single-nucleotide polymorphism (SNPs). This article reviews the association of gastrointestinal tumors (esophageal, gastric, colon, liver, gallbladder, and pancreatic tumors) with VDR single nucleotide polymorphisms.