Introduction: Local recurrences following radical resections of the colon are generally unlikely. The relapse is most often retroperitoneal; these are, in fact, unresolved during the operation regional lymphatic metastasis or distant lymph metastasis, such as retropancreatic, which do not enter the volume of operative intervention. Case presentation: We present the case of a 52-year-old man operated in our clinic for recurrent colorectal cancer and we discuss lymphatic dissection in colon cancer and present enlarged lymph dissection and extirpation of retroperitoneal tumor as an alternative to chemotherapy and as a safe strategy for treatment in certain cases of relapse. Conclusion: Survival in patients with local recurrence and peritoneal metastasis treated with systemic chemotherapy alone is extremely unsatisfactory and 5 years survival in patients with peritoneal metastasis of colorectal carcinoma treated only systemic chemotherapy is only achieved as an exception. In such cases, extended lymphatic dissection is an alternative to chemotherapy, with very good close results and satisfactory distant results, especially in patients categorically refusing non-adjuvant or adjuvant chemotherapy.