Appropriate Running Speed for Physical Rehabilitation in BrainInjured Young Mice - Abstract
Physical exercise is beneficial for functional recovery after brain injury. For effective rehabilitation, the determination of appropriate running condition is an important challenge. In the present study, we examined the running parameter for treadmill exercise in a mouse model of neonatal hypoxic-ischemic brain injury. The mice performed exhaustive runs and incremental test to determine their critical speed (CS) and the velocity at the lactate threshold (vLT). The CS and vLT were significantly different between the normal mice and brain-injured mice. It was also found that the CS was not significantly different from vLT. According to this study, CS and vLT could be valuable parameters for rehabilitation in a mouse model of neonatal hypoxic-ischemic brain injury