Khat can be characterized as a green plant that belongs to the family of Celesterece. Khat”s is commonly different in terms leaf color, size and the plant height. The main addictive substances in khat leaves are the cathinone and cathine (Schedule I and III drugs, respectively), which are prohibited by the United Nations’ International Convention on Psychotropic Substances. Cathinone is the most active khat alkaloid that has many effects on the cardiovascular system such as increases blood pressure, has positive inotropic and chronotropic actions in isolated atria and elevates heart rate. Common khat usage in the long-term has been correlated with various health effects, involving oesophagitis, gastritis, duodenal ulcer, hepatic cirrhosis, autoimmune hepatitis, migraine, cerebral haemorrhage, pulmonary oedema and myocardial infarction. With respective to psychotropic effects, khat perhaps generates euphoria, elevated confidence, and enhanced alertness. In terms of adverse psycho-logical effects, khat can contribute to such conditions as depression, anxiety, mood instability, and mania. Amphetamine also shows vasoconstrictive action by stimulating the release of noradrenaline from sympathetic nerves and may participate in acute myocardial infarction. Catecholamines induce platelet aggregation and cause transient occlusion of the coronary vessels, which further becomes severe by an increase in myocardial oxygen demand induced by catecholamines. In addition to its role as a risk factor for acute myocardial infarction, amphetamine abuse may lead to chronic cardiomyopathy, pulmonary heart disease, necrotizing vasculitis, and intracranial hemorrhage. Cathinone also plays a role in the development of congenital heart disease.