There is an urgent need to reduce the growing global problem of children under 12 years old using drugs. The Child Interventions for Living Drug-Free (CHILD) Curriculum has been developed and trained around the world to help practitioners treat children between the ages of 4-12 for drug use problems. This mixed-methods study aimed to determine the barriers and benefits for practitioners in implementing the CHILD intervention in countries around the world. N=109 participants completed a survey from 30 different countries with quantitative and open-ended written response options. These online survey results show that drug use, including synthetic drugs, is widespread among children. Participants reported high concern about child drug use in their communities with 74% citing it as the most important priority for families and policymakers to address. A total of 71% of respondents reported using some skills of the CHILD curriculum to help children or families always or usually, which reflects the utility and applicability of the training and its materials. CHILD implementation barriers included awareness and understanding, access to resources, cultural barriers, financial constraints, staff training, and program integration. The survey participants recommended ways to further upscale CHILD’s implementation. Recommendations included raising awareness about child substance use disorders vulnerabilities, building partnerships and increasing specialized facilities for children with SUD and integrating the CHILD curriculum into educational systems and national standards. Finally, a listening group with 75 clinicians and policy implementers exploring how CHILD could be implemented in the USA yielded eight qualitative themes that highlighted the need for CHILD training and engaging in advocacy efforts to influence policy and secure support from governmental and non-governmental entities. Taken together, these results provide needed data to guide the tailoring of CHILD for different settings including the USA where children can be identified, assessed, and treated for drug use problems.