Difficult Prediction of Exacerbation of Interstitial Pneumonia after Lung Cancer Resection - Abstract
Background: Postoperative acute exacerbation of Idiopathic Interstitial Pneumonia (IIP) is known to be a catastrophic complication in the surgical treatment for primary lung cancer with concomitant IIP. Investigation of clinical factors associated with postoperative acute exacerbation of IIP in primary lung cancer patients was conducted.
Methods: Between 2000 and 2009, 5630 lung cancer patients underwent surgical resection in ten institutes in north Japan (Hokkaido); wherein, 249 patients (4.4%) had concomitant IIP. Univariate logistic regression models were used to determine risk factors for exacerbation of IIP in 36 clinicopathological factors (preoperative demographic data, serum data, pulmonary function, comorbidity, operative data, and pathological data).
Results: Nine of 249 patients (3.6%) developed acute exacerbation of IIP and 7/9 patients died of the exacerbation. The univariate analyses showed no risk factor for postoperative acute exacerbation of IIP.
Conclusion: It is very difficult to predict the occurrence of acute exacerbation of interstitial pneumonia after surgical treatment of patients with lung cancer and interstitial pneumonia. Further factors or parameters should be investigated to predict the occurrence.