Expression and Significance of CD4, CD45 In Patients with NonSmall Cell Lung Cancer - Abstract
Objective: To study the clinical significance of CD4 and CD45 expression in patients with non-small cell lung cancer.
Methods: Biopsies from 140 patients with non-small cell lung cancer in Weifang Second People’s Hospital from January 2011 to December 2015 were collected and made into tissue microarray. The expression of CD4 and CD45 in tissue microarray was detected by immunohistochemistry. The overall survival (OS) of patients was followed up by telephone in August 2020. Graphpad primes 8 and BIM SPSS statistics 22 were used for statistical analysis.
Results: Immunohistochemical staining showed a significant positive correlation between the expression of CD4 and CD45 from the same patients (Person correlation=0.4, P<0.0001). Kaplan-Meier survival analysis showed that the OS of CD4high patients was higher than that of CD4low patients (log-rank=0.0456); the OS of CD4highCD45high patients was higher than that of CD4lowCD45low patients (log-rank=0.0362). No significant difference was found in OS between CD45high and CD45low patients (log-rank = 0.5454).
Conclusion: There was a positive correlation between CD4 and CD45 in non-small cell lung cancer, and the expression of CD4 and CD45 in tumor tissue was positively correlated with OS.