Given neoadjuvant therapy has potential to increase overall survival before oesophagectomy, neoadjuvant chemotherapy or chemoradiotherapy are recommended before the curative surgery for patients with resectable locally advanced esophageal cancer(LAEC), but the optimal strategy remains inconclusive. Here, we report a case about a patient with LAEC who achieved a pathologically complete response after neoadjuvant immunochemotherapy. It is necessary to implement more clinical trials to determine which neoadjuvant therapy is more beneficial.