Exercise-Induced Anaphylaxis is potentially fatal phenomena. Unlike common allergic reactions related to allergens like foods, insect stings, or drugs, this unusual illness is characterized by the onset of anaphylactic symptoms during or immediately after physical activity. We are presenting herewith a 27-year-old male presented with signs and symptoms of anaphylaxis following exercise. The patient was previously healthy with no known medical history, and not on any medications. He denied any known allergies to food or medications. However, he reported multiple previous episodes of an itchy rash while jogging outdoors but was never as extensive as this episode. We managed him successfully with medications. A literature review suggests only few cases are reported, so far. Despite reported potential therapies, research gaps persist, emphasizing the need for anticipation, prompt recognition by exclusion of other causes, and appropriate investigations are essential for successful outcome.