Background: Accurate preoperative risk stratification is essential in patients undergoing coronary artery bypass grafting (CABG). EuroSCORE II is a commonly used risk prediction model for estimating operative mortality in cardiac surgery. Objective: To evaluate the accuracy of EuroSCORE II in predicting early postoperative mortality in patients undergoing isolated CABG. Materials and Methods: This retrospective observational study included 73 patients who underwent isolated CABG at a tertiary care center over a six month period. Data were collected from Medical Records Department case sheets. EuroSCORE II was calculated using standard preoperative variables, and patients were categorized into low, moderate, and high-risk groups. Predicted mortality was compared with observed in-hospital mortality. Results: The overall observed mortality was 8.2%. Mortality occurred predominantly in the high-risk EuroSCORE II group. A statistically significant association was observed between EuroSCORE II risk categories and postoperative mortality (p = 0.00001). No significant independent association was found between age or ejection fraction and mortality. Conclusion: EuroSCORE II is a useful and reliable tool for risk stratification and prediction of early mortality in patients undergoing isolated CABG.