SARS CoV-2 virus detection using rapid Antigen diagnostic kit, is now widely used for detection and screening purposes. Self-testing antigen kits are recommended for high-risk individuals. The present study was done to see the utility of self-testing SARS CoV-2 kits as routine screening in hospital frequented by patients in nephrology services. Patients were divided into two groups those who can self-test themselves using self-antigen detection test and another group who were assisted in doing the same test and results compared. Out of 206 individuals who were involved in the study, 43 out of 206 (20.8%) showed positive results. 137 persons who self-tested had a significantly higher rate of failed tests in the first attempt compared to those who were in assisted antigen detection test group (p<0.05). All patients who were found positive underwent mandatory RTPCR test. The detection of viral positive cases was similar in both groups and the sensitivity of the test was above 92% in both groups when compared with RTPCR results. Conclusion: Self- Antigen detection test as routine screening during pandemic is useful point of care test for early detection and prevention of the spread of COVID-19 infection in hospital frequent visitors. Assisted antigen test must always be encouraged to avoid first time failure.