Department of Pharmaceutics, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, India - Abstract
The aim to develop a locally effective colon targeted therapeutic system in the form of a multiparticulate oral formulation that might provide an improved efficacy with a significant reduction in dose and systemic toxicity and improved quality of life for the treatment of Irritable Bowel Disease (IBD). The formulation of beads develops by inotropic gelation. The effect of various formulation parameters such as ratio of gellan gum and locust bean gum were studied for drug loading, and entrapment efficiency. To retard the drug release in the stomach and achieve a pH dependent release at colonic pH of 7.4 a polymethacrylate base coating carried out by dip coating method. The surface analysis was carried out by scanning electron microscopy (SEM).
In vitro analysis of coated formulation shows much retarded release in comparison of uncoated formulation. The in vivo release performance of the developed colon specific formulation was carried out by gammascintigraphy.