Recent Articles
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March 21, 2024 Research Article
Abstract The binding strength of COVID-19 variants, Omicron BQ.1, XBB.1.5, XBB 1.16, FE.1, EG.5, and BA.2.86, with the ACE-2, was calculated and evaluated with previous variants. The binding inhibition of various compounds (including PF07321332, Molnupiravir,.....
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November 22, 2023 Mini Review
Abstract Herbal cosmetics are now become more interesting by people as compared to synthetic cosmetic products. Herbal sunscreen is available in various forms which can be topically available. The objective of this study is to collect current data regarding .....
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November 25, 2023 Research Article
Abstract The cancer drug trial candidate Tipifarnib and its derivatives were subjected to a thorough QSAR analysis in the current study for the undertreated disease anti-Chagas. The study was effective in identifying the crucial structural elements that regul.....
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July 07, 2023 Review Article
Abstract Abstract A small series of N-substituted-alaninyl and N-substituted-glycinyl-triazolyl oxazolidinone derivatives were evaluated against susceptible and drug-resistant Gram-positive cocci, including multidrug-resistant mycobacterial and linezolid-resi.....
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June 20, 2023 Short Communication
Abstract Cancer is a hyper-proliferative disorder, which induces deformation of a natural cell by genetic mutations in DNA. Due to the high death rate associated with cancer, it is a major health problem for developing countries. Chemotherapy, Radiotherapy, a.....
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August 13, 2021 Research Article
Abstract Lamivudine is a cytidine analogue reverse transcriptase inhibitor that is active against HIV-1, HIV-2, and HBV; it is approved for HIV in adults and in children aged 3 months or older. Lamivudine enter cells by passive diffusion and is phosphorylated.....
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June 24, 2021 Review Article
Abstract Ganciclovir is an acyclic guanine nucleotide analogue and valganciclovir is the L-valyl ester prodrug of ganciclovir. Ganciclovir inhibits all herpes viruses and is especially active against cytomegalovirus. Ganciclovir inhibits viral DNA. Ganciclovi.....
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April 27, 2021 Review Article
Abstract Ampicillin is an aminopenicillin and is more active than penicillin G. Ampicillin is destroyed by ?-lactamase and is co-formulated with sulbactam an inhibitor of ?-lactamase. Ampicillin is bactericidal and it is active against meningococci, Listeria .....
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April 12, 2021 Review Article
Abstract Aciclovir is an acyl guanine nucleoside analogue that lacks the 2’ and 3’ positions normally supplied by ribose. Aciclovir is the prototype of a group of antiviral agents that are nucleoside congeners that are phosphorylated intracellularly by a .....
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April 18, 2018 Research Article
Abstract The aim to develop a locally effective colon targeted therapeutic system in the form of a multiparticulate oral formulation that might provide an improved efficacy with a significant reduction in dose and systemic toxicity and improved quality of lif.....
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March 21, 2018 Short Communication
Abstract While early detection technology for cancer has been peruse as one of the priorities to extend life expectancy, small molecule therapeutic drugs treatment remains as the first line of defend again cancer problems. The hormone dependency for Estrogen .....
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July 13, 2017 Review Article
Abstract It can be obtained from lichens biologically-active extracts and pure substances, many of them of phenolic nature. They are usually obtained by using organic solvents, such as diethyl ether. In this paper the usefulness of ether for the obtainment of.....
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April 13, 2017 Research Article
Abstract Clinical trials have demonstrated that in patients with type 2 diabetes (T2DM) and albuminuria, dipeptidyl peptidase 4 inhibitors (DPP-4i) are associated with urine albumin-to-creatinine ratio (UACR) reduction. We examined whether a similar effect is.....
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March 08, 2017 Short Communication
Abstract New small drug like compounds are developed based on the selection of more specific targets considering the interrelationship of three knowledge fields: rational drug design/computer-aided drug design (CADD), chemical synthesis and biological evaluat.....
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November 27, 2015 Research Article
Abstract A fluorimetry comparison study has been established for the labeling of human serum albumin (HSA) using two boronic acid functionalized squarylium dyes, one is monofunctional boronic acid dye (SQ-BA4) while the other one is bifunctional boronic aci.....
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June 10, 2015 Research Article
Abstract Prednisolone is commonly indicated for the treatment of ocular allergy, inflammation and uveitis. Topical administration of prednisolone suffers several limitations, which include poor aqueous solubility, rapid tear turnover rate, high cellular efflu.....
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April 09, 2015 Research Article
Abstract A series of stereoisomeric prodrugs have been designed to examine their efficacy in generating higher absorption relative to prednisolone. Prodrugs have been synthesized and identified with LC/MS/MS and NMR analysis. Prodrugs have been for their aqu.....
