The objective of this research work was to design, characterize and evaluate microemulsion. The anti-fungal drug miconazole nitrate has a low solubility in water, leading to reduced therapeutic efficacy. In addition, the size of the droplets in such microemulsions remains constant and ranges from (0.02- 0.20µm). Microemulsions dramatically enhance the therapeutic efficacy of drugs and reduce the volume of the drug delivery vehicle, thus minimizing toxic side effects. Miconazole-nitrate microemulsions were developed and assessed for topical skin delivery, prepared through spontaneous emulsification with isopropyl palmitate as an oil phase. The surfactant phase included span 80 and co-surfactant polyethylene glycol 400 (peg 400). As per the Placket Burman DoE F15 formulations were developed using independent variables concentration of oils, surfactant and co-surfactant. Microemulsions was characterized for various parameters like, viscosity, Density, pH, drug content, surface morphology, Particle size determination, Zeta potential, In-vitro drug diffusion study. The optimum formulation F4 and F15 showed 100% and 98.75% drug diffusion in 3 hrs and 5 hrs. Desired viscosity F4 showed 48.7 ± 43.2cps and F15 showed 56.8 cps, Density F4 showed 0.97g/cc and F15 showed 0.98g/cc, comfortable pH F4 showed 7.07 ± 0.1 and F15 showed 6.97 %, drug content F4 showed 86.45% and F15 showed 94.06%, F4 showed 0.02µm and F15 showed 0.14µm particle size and zeta potential of F15 showed -19 ± 8.24 mV of globule size, this outcome signified its potential suitability as a carrier for effectively administration of miconazole through topical delivery.