Purpose: To assess longer follow-up (more of 20 years) in children whose received chemotherapy during pregnancy, to detect the risks that can appear an late adult lifePatients: All children ( now: adults) were analyzed the presence of some severe health problems , that can be associated with the use of cytotoxic drugs , also the academic and work if they present some problems with learning, environment, behavior , social development and parenthood Results: At longer time, median 23.4 (range 16-37) years, 201 children are alive, with a normal social, academic and working situations. One, die at 17 years (suicide associate to drugs). No cardiac, neurological damage were observed. Different disease were according to the age, only a case of diabetes mellitus were observed. Presence of any type of cancer were not observed. The social, academic, working and social environment were normal according to the economic status. Conclusion: In this final report of our group, we confirmed that the use of chemotherapy during pregnancy did not affect the life of children, and the use of adequate treatment improved the outcome of the mothers.