Recent Articles
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July 01, 2024 Research ArticleAbstract Iron deficiency anemia (IDA) is the most prevalent cause of anemia worldwide. Studies conducted in Riyadh and Tabuk have revealed a significant lack of understanding regarding IDA and its prevention. Consequently, there is a pressing need to enhanc.....
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June 14, 2024 Research ArticleAbstract Purpose: To assess longer follow-up (more of 20 years) in children whose received chemotherapy during pregnancy, to detect the risks that can appear an late adult lifePatients: All children ( now: adults) were analyzed the presence of some severe hea.....
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March 23, 2024 Short CommunicationAbstract A previously healthy 4-year-old female presented for a cough that was not responsive to treatment of inhaled corticosteroid (ICS). Pertinent history included meconium aspiration with no respiratory support required and a course of confirmed SARS-C.....
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March 02, 2024 Case ReportAbstract Waldenström’s Macroglobulinemia (WM) is a rare lymphoproliferative disorder that presents a wide range of peculiar clinical manifestations; among them Bing-Neel Syndrome (BNS), concerning infiltration of the Central Nervous System (CNS), is extrem.....
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January 24, 2024 Review ArticleAbstract Statement of the Problem: Impairment of the blood coagulation system remains a relevant issue in clinical practice. A striking example of this is the fact that despite the administration of anticoagulant therapy, up to 35% of COVID-19 patients were.....
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January 05, 2024 Case ReportAbstract Despite significant survival increment due to treatment improvement, multiple myeloma (MM) remains an incurable disease. We herein describe a unique patient that is not only a MM long survivor despite adverse features, such as the occurrence of extra.....
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June 20, 2023 Review ArticleAbstract Erythrocyte serological phenotyping is very important in determining the identity of suspected alloantibodies and also to facilitate the identification of antibodies that may be formed in the future. Serological phenotyping is a conventional method w.....
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April 15, 2023 Letter to the EditorAbstract We retrospectively examined the impact of platelet refractoriness on survival in acute myeloid leukemia (AML) patients, an occurrence that may significantly impact even fit older patients [1]. We compared platelet-refractory versus AMLcontrol .....
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March 24, 2023 Case ReportAbstract Introduction: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease present with the classic pentad of microangiopathic hemolytic anemia (MAHA), fever, neurologic changes, thrombocytopenia, and renal dysfunction. In a diagnostic dil.....
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March 22, 2023 Research ArticleAbstract Introduction: Blood transfusion is a medical act requiring certain specificity. Our objective is to evaluate the transfusion practice of healthcare personal involved in the act of transfusion. Methods: We carried out a prospective descriptive cross-.....
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May 28, 2021 CommentaryAbstract CoV-2 infection-induced thrombotic thrombocytopenia purpura [TTP] is life-threatening event often observed amongst critically ill CoV-2 patients and intriguingly subsequent to vaccination, as a rare event, with an incidence about 10 cases per million.....
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May 15, 2021 Case ReportFirst-In-Human High-Cumulative-Dose Mesenchymal Stem Cell therapy in Multiple Myeloma: A Case ReportAbstract Multiple myeloma (MM) is a highly malignant cancer characterized by the proliferation and accumulation of monoclonal plasma cells in the bone marrow along with end-organ damage due to the underlying disorder. Despite the remarkable progress in the tr.....
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January 25, 2021 Research ArticleAbstract Background: Blood safety is a major issue all over world-wide in transfusion medicine. For this reason, blood donor selection is important for the safety of donors and recipients as well as for maintaining an adequate blood supply. Detailed analysis .....
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October 29, 2020 Review ArticleAbstract At the end of 2019, a new coronavirus (SARS-CoV-2) was identified in people living in the city of Wuhan in China. The first people identified as infected went to the city’s seafood market, where live animals were also sold. Since the appearance of .....
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October 29, 2020 Research ArticleAbstract Objectives: The paper presents results of 27- year epidemiological study of screening and follow-up haemoglobinopathies in Slovakia.Methods: Between 1993 – 2020, in two research centres in Bratislava and in one centre in Kosice, carriers of beta-th.....
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March 22, 2018 Case ReportAbstract Seven years follow-up after the birth of a healthy infant, who became a bone marrow donor two years after delivery to his sick sibling, after successful preimplantation genetic diagnosis (PGD) testing by both cleavage stage and blastocyst biopsy for .....
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March 12, 2018 Opinion Article
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January 30, 2018 Case ReportAbstract P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside on the Red Blood Cells (RBCs) of almost all individuals worldwide. P1PK blood group system antigens include P1, Pand PKantigens. Among these, P1 K phenotype i.....
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January 26, 2018 Editorial
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November 29, 2017 Mini ReviewAbstract Anemia is a frequent debilitating problem, negatively affecting the quality of life of cancer patients. It is associated with poor prognosis and has been directly correlated with fatigue. Despite being more common in hematologic malignancies, anemia .....
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November 29, 2017 Research ArticleAbstract Background: Mixed lineage leukemia (MLL) is one of the most frequently involved genes in hematologic malignancies, in particular in some forms of acute leukemia, both lymphoblastic and myeloid. In adult ALL, MLL gene re-arrangement is found in 7% cas.....
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October 23, 2017 Case ReportAbstract Invasive fungal infections, which lead to increased morbidity and mortality, are commonly observed in patients with hematologic malignancies. Pulmonary infiltrates associated with bacterial and fungal infections are often encountered in patients wit.....
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September 28, 2017 Review ArticleAbstract Greece is one of the few countries with high incidence of ?-thalassemia trait in which prolonged national programs for prevention and treatment were implemented. Evaluation of treatment program in 1979, demonstrated amelioration of the main clinic.....
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August 25, 2017 Research ArticleAbstract MYH9-related disease is an autosomal dominant hereditary macro thrombocytopenia caused by mutations in the MYH9 gene which encodes the non-muscular myosin heavy chain type IIA. The patients have mild clinical bleeding, grayish-blue inclusions in gran.....
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June 30, 2017 Case ReportAbstract Hemosuccus pancreaticus (HP) is a rare cause of upper gastrointestinal bleeding. Case of haemophilia A presenting as HP has not been reported. We describe the case of a 50 year old patient, who presented with complaints of melena, he was initially di.....
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June 26, 2017 Review ArticleAbstract The inherited platelet disorders are heterogenous and rare diseases. These disorders are normally associated with bleeding diasthesis due to either a platelet functional abnormality or haemostatic procoagulant defect. They can be classified into mole.....
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May 26, 2017 Research ArticleAbstract Background: Blood transfusion is an essential element of health care which saves life. As a result of the advances in clinical sciences and population increase, the need for blood is growing day by day all over the world. One percent of the populatio.....
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April 21, 2017 Case ReportAbstract Primary non-secretory Plasma cell leukemiaisa rare diagnosis with only few cases reported so far. Here we report a case of a non secretory Plasma cell leukemia diagnosed on flow cytometry, as atypical morphology and negative serum and urine protein e.....
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April 19, 2017 Short CommunicationAbstract The concurrence of malaria and hemoglobinopathies, observed in malaria endemic regions, reflects the phenomenon of natural selection. The incidence of alpha and beta Thalassemia is very high at the seaside locations related with malaria in the worldw.....
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November 11, 2016 Review ArticleAbstract Immunological response during pregnancy is essential to maintain a successful pregnancy. There seems a dysruption in immunological tolerance to foetus by maternal immune system during pregnancy which results in pregnancy-related complications, such a.....
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October 22, 2016 Short CommunicationAfrican Sickle Beta Zero-Thalassemia Patients Vs Sickle Cell Anemia Patients: Similar Clinical Features but Less Severe HemolysisAurélien Sokal1,2# Marie Dubert1,2# Dapa Diallo3 Saliou Diop4 Aissata Tolo5 Suzanne Belinga6 Ibrahima Sanogo5 Ibrahima Diagne7 Guillaume Wamba8 Kouakou Boidy4 Indou Deme Ly7 Moussa Seck3 Blaise Felix Faye3 Ismaël Kamara4 Youssouf Traore2 Lucile Offredo2 Jean-Benoît Arlet1 Xavier Jouven2,9 Brigitte Ranque1,2*Abstract Introduction: S-? zero thalassemia (S?0) represents less than 5% of the sickle cell disease (SCD) phenotypes. Although the S?0 phenotype is believed to be as severe as the homozygous (SS) sickle cell anemia, the two phenotypes have rarely been compar.....
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September 23, 2016 Review ArticleAbstract In patients of hemolytic disorders, presence of excessive free hemoglobin (Hb) in plasma causes several cytotoxic effects. Hb being a potent scavenger of nitric oxide (NO) impairs the NO-mediated vasodilatory functions, thus promoting blood vessel co.....
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September 23, 2016 Review ArticleAbstract At the beginning of 90s’, recombinant FVIII/FIX concentrates were introduced in the hemophilia therapy and in the following 20 years they underwent a progressive improvement of their characteristics, moving from 1st to 2nd and finally to 3rd genera.....
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August 30, 2016 Research ArticleAbstract Sports and physical activities have long been contraindicated for haemophiliacs, or they were restricted to a few activities such as swimming or walking. Recent progress in therapy has meant that haemophiliacs are now encouraged to participate in spo.....
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August 10, 2016 Research ArticleAbstract Background: Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. A number of molecular abnormalities have been described involving several genes such as FLT3, NPM1, CEBPA.....
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July 11, 2016 Research ArticleAbstract Background: Myeloproliferative neoplasms (MPN) are the most common myeloid neoplasms in Eastern Morocco. The aim of this study is to determine the epidemiological, clinical, biological and therapeutic characteristics of MPN in this region. Methods.....
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June 14, 2016 Mini ReviewAbstract Hepatocellular carcinoma (HCC) remains a major cause of mortality in patients with chronic liver disease worldwide. Early detection of HCC is critical to providing effective treatment and can have a significant impact on survival. Currently available.....
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May 20, 2016 Research ArticleAbstract Objectives: To evaluate the agreement between parents and children with sickle cell disease (SCD) in rating children’s oral health- related quality of life (OHRQoL). Methods: A cross sectional study was conducted with children aged 8 to 14 years.....
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March 07, 2016 Short CommunicationAbstract Unequal granular temperature theory predictions agree with measurements of RBC and platelets in blood vessels. The effect of shear on LDL transport is predicted only qualitatively.
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January 22, 2016 Review ArticleAbstract Acetylsalicylic acid (ASA) is the most widespread antiplatelet agent used now a day due to its efficacy and low cost. However, several side-effects are well-known to limit ASA usage. This review covers the recommended guidelines for ASA usage for pri.....
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December 02, 2015 Research ArticleAbstract Objectives: To investigate the effects of Glivec on some aspects of immunity in CML patients. Patients and Methods: We prospectively assessed some immunological parameters in 50 Nigerian CML patients before and six months into Glivec therapy. FBC,.....
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August 14, 2015 Research ArticleAbstract Introduction- Anaemia is a major public health problem in developing countries like India. Kavaratti Island, Lakshadweep is a remote island located in Arabian sea. There is no data on anaemia available from here. Objectives of this study are to exami.....
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July 27, 2015 Short CommunicationAbstract Sickle cell disease (SCD) is the most common inherited blood disorder and affects approximately 100,000 individuals in the United States. Once confined to childhood, improvements in early diagnosis through universal newborn screening and coordinated .....
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July 07, 2015 Review ArticleAbstract Multiple myeloma is a disease of malignant plasma cells in the bone marrow. Interaction of malignant plasma cells with the bone marrow microenvironment plays a key role in the pathogenesis of myeloma. Recognition of potential adverse cytogenetic and .....
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May 15, 2015 Case ReportAbstract We report a unique case of relapsed Langerhans cell histiocytosis (LCH) occurring 29 years after initial diagnosis. Recurrence was temporally related to discontinuation of methotrexate, originally used as a treatment for the patient’s poorly respon.....
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November 03, 2014 Case ReportAbstract A 5-year-old boy, presented a paraparesis and was referred for pelvic neuroblastoma based on MRI finding. The BMA performed in this context revealed an AML M2 with t(8;21) confirmed. The diagnosis of Myeloid sarcoma was confirmed by the histological .....
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November 03, 2014 Research ArticleAbstract Background: Accumulating evidence suggests that genetic variants, including deletion and single nucleotide polymorphism (SNP) have role in the genesis and progression of various cancers. BIM (also known as BCL2L11) is a proapoptotic protein that is e.....
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November 03, 2014 Research ArticleAbstract Allogeneic hematopoietic stem cell transplant is an important modality of treatment for patients bearing malignant and benign hematologic diseases, representing a chance of cure. As every treatment, it has a treatment-related mortality influenced by.....
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November 03, 2014 Review ArticleAbstract Stem cells application in regenerative medicine is the new goal on stem cell research. However, still exist some problems to use stem cells safely mainly by immune rejection and by cancer development issues. One type of stem cells, the mesenchymal st.....
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November 03, 2014 Review ArticleAbstract Multiple myeloma, a malignant proliferation of plasma cells, is still incurable. This disease, 1% of all human malignancies, is responsible for almost 2 % of the whole cancer related mortality. In this review the authors summarize their 20 years expe.....
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July 08, 2014 Review ArticleAbstract Chronic Myeloid Leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells caused by a formation of the BCR-ABL1 chimeric gene, which encodes an aberrant tyrosine kinase with oncogenic activity. Despite the introduction of Tyr.....
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July 08, 2014 Review ArticleAbstract More than 10 years has passed since the first BCR-ABL Tyrosine Kinase Inhibitor (TKI), iatinib, introduced into clinical practice in treatment for Chronic Myeloid Leukemia (CML). Addition to the development and clinical usage of more potent second g.....
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July 08, 2014 Review ArticleAbstract Most newly diagnosed CML patients in the Chronic Phase (CP), when treated with imatinib, achieve durable responses. However, a small percentage of these patients as well as most advanced-phase patients relapse on imatinib therapy. Among several resis.....
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July 02, 2014 Research ArticleAbstract Malaria infection is a major public health problem and cause of morbidity and mortality particularly among children and pregnant women in tropical and subtropical regions of the world. The aim of this present study was to determine the effect of plas.....
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June 06, 2014 Research ArticleAbstract Several studies have shown that treatment of polycythemia vera (PV) and essential thrombocythemia (ET) with interferon-alpha2 (IFN-alpha2) is associated with a decrease in the JAK2 V617F mutational load together with complete hematological responses .....
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March 03, 2014 Mini ReviewAbstract Until recently, the Vitamin K antagonist (VKA) warfarin was the only oral antioagulant available for clinical use. However, with the US FDA approval of new oral anticoagulants (NOAs) such as dabigatran, rivaroxaban and apixaban, there currently exis.....
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February 14, 2014 Case ReportAbstract A 7 year-old boy with T-cell acute lymphoblastic leukemia (T-ALL) was under treatment according to the ALL BFM 2000 protocol. Cerebrospinal fluid analysis did not reveal any blast cells at the beginning of the therapy. The patient developed bilateral.....
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November 22, 2013 Editorial
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August 26, 2013 Case ReportAbstract A 67-year-old woman was admitted to our department presenting with rash, rib pain and anemia. The patient had had a rash for 20 years, and was previously diagnosed with multiple myeloma at her local hospital. The patient doubted both the diagnosis of.....
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September 06, 2013 Case ReportAbstract Bronchiolitis obliterans (BO), characterized by progressive and irreversible respiratory failure, is one of rare complications associated with graft-versus-hostdisease (GvHD) following allogeneic hematopoietic stem cell (HSC) transplantation. We repo.....