P1 K : A Rare Blood Group Phenotype - Abstract
P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside on the Red Blood Cells (RBCs) of almost all individuals worldwide. P1PK blood group system antigens include P1, Pand PKantigens. Among these, P1 K phenotype is very rare and the RBCS of these individuals express P1, PKantigens. The high incidence antigen, P, is missing and anti-P antibody is present in the serum. Naturally occurring anti-P is present in the serum of individuals with the rare globoside-deficient phenotypes p, P1 k, and P2k and has been implicated in hemolytic transfusion reactions,
Donath-Landsteiner antibody as well as unfavorable outcomes of pregnancy. When an individual with P1K phenotype needs blood transfusion, they can receive only autologous blood or blood from another P1K phenotype or p phenotype (if P1K blood is not available). We report a case of a young boy with P1K phenotype, anti-P and px2 antibodies who developed a severe hemolytic transfusion reaction and were successfully treated conservatively