The Incidence of Adverse Reaction and Its Predictors among Ethiopian Whole Blood Donors: A Retrospective Cohort Study - Abstract
Background: Blood donations are generally well tolerated but they are not completely without risk. Adverse reactions are complications of blood donations with significant donor discomfort and negative effect on donor satisfaction and return for donation. Published evidence from Ethiopia on this area is scanty. Objective: This study assessed the incidence of adverse reaction and its predictors. Methods: A cohort study was conducted using national data of volunteer whole blood donors. We analyzed the data by SPSS 26. We performed modified binary logistic regression to identify predictors of adverse reaction. Results: We included 6019 donors in the analysis. The incidence of adverse reactions was 3% (95% CI: 2.56%-3.42%). A female had 83% lower chance; a young donor (<23 years old) had 69% lower risk compared to ? 23 years old; a donor who donated at mobile donation site had 94% lower chance of having adverse reaction. A donor who donated 450ml had 3 times higher chance compared to that who donated 350ml; first-time donor had at least 34% lower risk of having adverse reactions. Conclusions: Interventions to reduce adverse reactions should consider sex, age, donation site, the volume of blood donated and donation history of the donors.