Update on Immunology, Pathogenesis and Management of Precalmpsia-Revisted - Abstract
Immunological response during pregnancy is essential to maintain a successful pregnancy. There seems a dysruption in immunological tolerance to foetus by maternal immune system during pregnancy which results in pregnancy-related complications, such as recurrent spontaneous abortions. Among 8% of pregnancies preeclampsia stands out as a leading cause of maternal and perinatal mortality and morbidity. This presents as pregnancy-specific disease characterized by the development of both hypertension and proteinuria yet at times it may progress into a multiorgan involvement with varying clinical manifestations. Although the precise etiology of the disorder is still unknown, deficient early placentation is particularly associated with early onset preeclampsia which is thought to be immunologically mediated. Despite various biomarkers available, prevention and prediction of preeclampsia are still not possible, symptomatic clinical management must focus on preventing maternal morbidity (e.g., generalized seizures of eclampsia) and mortality.