One of the leading causes of death worldwide and the primary cause of long-term disability in affluent nations is frailty and stroke. According to earlier research, there is a strong correlation between stroke patients death and frailty. The aims of this review to investigate the association of acute ischemic stroke and frailty patients. The search was performed using the keywords acute ischemic and stroke frailty. The review systematically analyzed existing literature to provide a comprehensive overview of associations, different factors and inflammatory biomarkers. This review addresses the factors associated with these two diseases, emphasizing the role of ageing, factors (diet, physical activity, smoking), genetic background, and the presence of subclinical illnesses in influencing the risk of both frailty and acute ischemic stroke. The association between frailty and ischemic stroke is underscored, with shared risk factors and potential bidirectional influences. Moreover, the review highlights the intricate links between inflammatory markers, frailty, and acute ischemic stroke. Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-?), Lymphocytes and C-reactive protein (CRP) play a dual role in inflammation and are associated with age-related morbidity, frailty and stroke. The conclusion is that frailty and acute ischemic stroke are closely linked, sharing risk factors and having bidirectional influences, highlighting the need for targeted interventions and improved healthcare strategies for affected individuals.