Recent Articles
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January 30, 2024 Review ArticleAbstract The interplay between trait mindfulness (TM) and values was investigated within a cohort of 580 (291 Females; Mean Age: 22.5 years) novice Indian meditators. Drawing upon Schwartz’s universal human values framework, the associations between TM and .....
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January 30, 2024 Research ArticleAbstract This study investigates the role of eudaimonic factors such as ‘quiet ego’ and ‘non-attachment’ in fostering resilience among young adults in urban India, examining the interplay of these constructs with gender, social media usage, and psycho.....
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February 29, 2024 Review ArticleAbstract During last decades several endogenous risk factors which participate in the development and progression of Alzheimer’s Disease (AD) have been identified. They include increased oxidative stress, chronic neuroinflammation, mitochondrial dysfunction.....
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February 29, 2024 Research ArticleAbstract Introduction: Medication overuse headache (MOH) is a secondary headache that occurs 15 or more days per month in patients with pre-existing headaches. It results from the excessive (10 or 15 days/month) use of drugs used as acute or symptomatic heada.....
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February 29, 2024 Mini ReviewAbstract Discontinuation of Antiepileptic Drugs (AEDs), primarily prompted by adverse effects, presents a formidable challenge in the management of epilepsy, impacting up to 25% of patients. This article thoroughly explores the clinical spectrum of Cutaneous .....
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January 30, 2024 Review ArticleAbstract Objective: Application of rapid health technology to evaluate the effectiveness, safety, and efficacy of Agatroban Injection in the treatment of acute ischemic stroke, providing evidence-based reference for selecting clinical treatment plans. Method:.....
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January 30, 2024 Case ReportAbstract The trigeminal artery, which is one of the major carotid-basilar anastomoses in the fetal period, regresses with the development of the posterior circulation in the prenatal period. In rare cases, when this regression does not occur but persists, i.....
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January 30, 2024 Case ReportAbstract Background: Stroke-like syndrome is a stroke mimic, usually common in the young and accurate diagnosis has considerable impact in terms of treatment choices and outcomes. Objectives: To emphasise the need for high index of suspicion and the need for .....
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December 29, 2023 Review ArticleAbstract Purpose: Developmental epileptic encephalopathies (DEE) are a group of conditions featuring drug-resistant epilepsies and a large spectrum of comorbidities, which result in an enormous psychosocial burden. In the last decade, the use of vagus nerve s.....
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December 29, 2023 Case ReportAbstract Background: The most frequent tumors of the spine are metastases. However, we present a particular case characterized by an atypical primary origin resulting in secondary lesions in both the spinal column and adjacent soft tissues - specifically, squ.....
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December 01, 2023 Clinical ImageAbstract We present a 62 year old female patient who gradually lost cognitive function, followed by gait disturbance and then urinary incontinence over the course of one year. She was investigated for potential Parkinson’s disease given the absence of heada.....
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October 31, 2023 Research ArticleAbstract Subacute stroke is a health, related problem that spans a period from two days to two weeks. This randomized controlled trial investigates the effectiveness of constraint, induced movement therapy (CIMT) and combined mirror therapy for inpatient reh.....
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September 30, 2023 Research ArticleAbstract COVID-19 has affected hundreds of millions of people around the world.
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July 31, 2023 Research ArticleAbstract Abstract Background and objective: In the hybrid assistive neuromuscular dynamic stimulation (HANDS) protocol, patients use EMG-controlled neuromuscular electrical stimulation (NMES) with a wrist splint for 8 hours a day for three weeks. The HANDS pr.....
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May 31, 2023 Mini ReviewAbstract Mini review summarizes the long-term studies of pathology of pneumococcal meningoencephalitis on children’s, adult autopsy material and in experiment provided by the author and its collaborators. Pneumococcal meningitis in most severe cases include.....
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May 31, 2023 Research ArticleAbstract Aim: To compare disease impact on functioning in patients with chronic fatigue syndrome receiving disability benefits and patients recovered and returned to work. Methods: Eighteen patients with CFS living in a Western Norway community with 11,500.....
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April 28, 2023 Review ArticleAbstract Psychotic depression is a distinct disorder with a different course and treatment than nonpsychotic depression.
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April 27, 2023 Short CommunicationAbstract Background: There is limited data available for the benefits of endovascular therapy (EVT) in elderly with large vessel occlusion (LVO) and the necessity of administering thrombolytic agent before mechanical thrombectomy (MT). Methods: We conducte.....
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January 23, 2023 Research ArticleAbstract Objectives: Caregivers of children with cerebral palsy suffer from a substantial burden. However, there is a need for more documentation of the various sources of burden during COVID -19 in low- and middle-income settings. Hence, we aimed to report t.....
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October 31, 2014 Review ArticleAbstract Microglial activation is one of common pathological findings in the lesions of many neurodegenerative diseases. In the 1980’s immunohistochemical studies, using anti-major histocompatibility complex class II (MHCII) antibodies identified activated .....
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March 10, 2014 Review ArticleAbstract Pío del Río Hortega first discovered microglia by histological staining with silver carbonate. He thought that microglia with highly branched fine processes in the healthy brain were quiescent and called these cells as resting microglia. After brai.....
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March 07, 2014 Review ArticleAbstract The etiology of schizophrenia remains unclear while, in many aspects, the neuropathology of schizophrenia has recently been reported to be closely associated with microglia dysfunction. Microglia, which are the major players of innate immunity in the.....
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September 19, 2014 Review ArticleAbstract We reviewed and compared the neuropathology of multiple sclerosis (MS), neuromyelitis optica (NMO), neuromyelitis optica spectrum disorders (NMOSD) and acute disseminated encephalomyelitis (ADEM) in Japan. Demyelinating lesions of MS are well circums.....
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October 21, 2014 Review ArticleAbstract The relationship between epilepsy and sleep is complex and dynamic. Sleep complaints and concomitant sleep disorders are common in people with epilepsy. Seizures and antiepileptic drugs can alter sleep architecture.There have been conflicting finding.....
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March 24, 2014 Review ArticleAbstract It is recognized that explosive blast Traumatic Brain Injury (TBI) may be a significant risk factor for seizure and consequently Post-Traumatic Epilepsy (PTE). This has importance clinically as the manifestation of seizures following a blast exposure.....
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April 14, 2014 Review ArticleAbstract Psychosis is a significant comorbidity for a subset of patients with epilepsy, and may appear in various contexts. Psychosis may be chronic or episodic. Chronic Interictal Psychosis (CIP) occurs in 2-10% of patients with epilepsy. CIP has been asso.....
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April 14, 2014 Review ArticleAbstract Both incidence and prevalence of epilepsy are high among the elderly patients. Epilepsy in the elderly differs in etiology, clinic features and prognosis. The most common etiological factor of epilepsy in the elderly is cerebrovascular diseases. Alth.....
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May 17, 2014 Review ArticleAbstract Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Despite its growing recognition amongst clinicians caring for patients with epilepsy, the exact pathophysiologic mechanisms behind SUDEP h.....
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May 10, 2014 Review ArticleAbstract Epilepsy is one of the most frequent neurological alterations affecting significantly the quality of life of the individuals who suffer it. Temporal Lobe Epilepsy (TLE) is one of the most severe types of epilepsies commonly presented in the world pop.....
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May 10, 2014 Case ReportAbstract Cases in which epilepsy and atrio-ventricular (AV) block coexist are unusual. A 31-year-old man presented with syncope. Holter ECG showed the second-degree AV block and the longest cardiac pause was 6.3 seconds. Even after receiving pacemaker, he rep.....
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May 10, 2014 Review ArticleAbstract Pure word deafness is a disorder of auditory verbal comprehension without dysfunction of speaking, reading, or writing. This rare symptom arises from bilateral lesions in the temporal lobes or disconnection between the primary auditory cortex and.....
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May 15, 2014 Review ArticleAbstract The neuropsychological consequences of Frontal Lobe Epilepsy (FLE) are not as well characterized as those of temporal lobe epilepsy. In the past 5 years though, new advances in behavioral assessment and imaging techniques have begun to more fully.....
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May 15, 2014 Review ArticleAbstract Lacosamide is a new antiepileptic drug that was has been approved as an adjunctive treatment of partial-onset seizures but also has potential in brain tumorrelated epilepsy. The medication’s novel mechanism of action of selectively enhances slow.....
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May 13, 2014 Research ArticleAbstract Minocycline is an antibiotic agent that has been shown to have neuroprotective properties in animal models of ischemia, Huntington’s disease and Parkinson’s disease. However, data are lacking regarding the neuroprotective effects of minocycline t.....
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September 13, 2013 Case ReportAbstract Patients with renal failure have a higher risk for cerebrovascular events and silent brain damage and a higher cardiovascular mortality rate when compared with the general population. We present two cases where alteplase was used for hemodialysis p.....
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June 30, 2017 Research ArticleAbstract Spasticity is a disorder commonly found in people having upper motor neuron lesion and whose involvement can happen at different levels. The Modified Ashworth Scale (MAS) is the most routinely used instrument in clinical practice to assign spasticit.....
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December 02, 2014 Mini ReviewAbstract n this viewpoint, we present the position that many neuropsychiatric phenomena in Parkinson’s disease (PD), which are often referred to as complications, mightbe more usefully conceptualised as symptoms, since they stem from the pervasive patte.....
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April 05, 2018 Research ArticleAbstract Attention deficit hyperactivity disorder (ADHD) is one of the neurodevelopmental disorder that is common in children. Most of the studies showed the impairment of visual attention in ADHD children. Little investigations have also addressed the differ.....
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September 19, 2014 Research ArticleAbstract Purpose: Cognitive impairment is commonly observed in patients with Temporal Lobe Epilepsy (TLE). Recently, volumetric analysis showed widespread cortical and subcortical atrophy in patients with TLE. In this study, we hypothesized that the diffuse a.....
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March 24, 2014 Research ArticleAbstract Autism Spectrum Disorder (ASD) is a heterogeneous, behaviorally defined neurodevelopmental disorder. Patients with ASD might also have co-morbid disorders such as intellectual impairment, epilepsy, and anxiety. Findings from questionnaire studies .....
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January 16, 2014 Review ArticleAbstract A common early non-motor symptom of Parkinson’s disease (PD) is sleep disturbance. Indeed, rapid eye movement (REM) sleep behavior disorder (RBD) and excessive daytime sleepiness (EDS) are predictors of PD. EDS and RBD are thought to be risk factor.....
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January 16, 2014 Research ArticleAbstract Background and Purpose: We examined the prevalence of clinical symptoms and cumulative dose of anti-parkinsonian drugs in Japanese patients with Parkinson’s disease (PD). Methods: We retrospectively reviewed the charts of patients (n = 1453; 650.....
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January 29, 2014 Mini ReviewAbstract Post-ischemic inflammation is an essential step in the progression of ischemic stroke. Infiltrating macrophages are known to serve as a key mediator of the innate immune response to danger-associated molecular pattern molecules (DAMPs) by their expre.....
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January 29, 2014 Case ReportAbstract Newer anticoagulants such as dabigatran have been widely used for the prevention of ischemic stroke in patients with nonvalvular atrial fibrillation (AF). A 64-year-old man treated with dabigatran 110 mg twice daily for chronic AF presented with tota.....
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January 29, 2014 Case ReportAbstract Acute basilar artery (BA) occlusion is associated with high morbidity and mortality rates. Progress has been made in endovascular treatments for acute ischemic stroke. Here, we present a case of acute basilar artery occlusion treated with stent place.....
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January 29, 2014 Research ArticleAbstract This study was performed to evaluate the preventive effect of cilostazol on bradycardia attacks during the carotid angioplasty with stenting (CAS) procedure. Among the 38 CAS procedures performed by the first author between April 2004 and May 2008, w.....
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January 29, 2014 Research ArticleAbstract Background and purpose: Moyamoya disease is a progressive occlusive disease of the cerebral arteries. Various vascular reconstruction surgeries have been reported, but the most appropriate procedure remains unclear. We have preferred to perform a com.....
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January 29, 2014 Research ArticleAbstract In the Aso area of Kumamoto Prefecture in Japan there are no hospitals where stroke patients can receive acute-period revascularization treatments. As transfer to an out-of-area hospital takes approximately an hour, the interval between stroke onset .....
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January 29, 2014 Research ArticleAbstract Retinal ischemia associated with carotid artery stenosis is an important clinical sign for the prevention of repeated retinal and cerebral ischemic attacks. In this study, we compared the cerebro-cardiovascular risk factors of patients with symptomat.....
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January 29, 2013 Editorial
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November 19, 2013 Review ArticleAbstract Stroke is the most common cause of neurological disability and impairs quality of life, resulting in early institutionalization. Atherosclerosis is a major contributor to stroke, which can be prevented by early recognition and management. Cardioankl.....
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August 19, 2013 Short CommunicationAbstract Background: Functional MRI (fMRI) basic cognitive paradigms such as the n-back have been shown to detect cognitive impairment (CI) in Multiple Sclerosis (MS). The immediate memory task/delayed memory task (IMT/DMT) detects varying degrees of working .....