Objective: Application of rapid health technology to evaluate the effectiveness, safety, and efficacy of Agatroban Injection in the treatment of acute ischemic stroke, providing evidence-based reference for selecting clinical treatment plans. Method: Retrieve Chinese and English medical databases and health technology evaluation websites. Two researchers independently screened and extracted literature based on inclusion and exclusion criteria, evaluated the quality of the literature, and summarized and evaluated the results. Method: A total of 12 articles were included, of which 8 were used for systematic evaluation and meta-analysis, and 4 were used for pharmacoeconomics research. Effectiveness analysis shows that the use of Agatroban injection can improve overall clinical efficacy, as well as improve neurological deficit scores and daily living activity scores. Safety analysis shows that the use of agatroban injection does not increase the risk of bleeding, and the safety is relatively high. The economic analysis results indicate that the use of agatroban injection has specific economic advantages. Conclusion: Agatroban injection has good efficacy, safety, and economic advantages in the treatment of acute ischemic stroke