Role of Lacosamide in Seizure Control in Brain Tumor Patients - Abstract
Lacosamide is a new antiepileptic drug that was has been approved as an
adjunctive treatment of partial-onset seizures but also has potential in brain tumorrelated epilepsy. The medication’s novel mechanism of action of selectively enhances slow inactivation of sodium channels and does not affect the rate of recovery. Lacosamide is available in both oral and intravenous preparation for ease of use and have has 100% bioavailability. Lacosamide is not metabolized by nor induces the activity of cytochrome P450. There is no significant interactions with other antiepileptic or chemotherapy drugs. Seizure control rate is very good with 50% respond rate range between 54-78%. The side effects of lacosamide are usually well tolerated, most commonly and include dizziness, blurry vision, nausea and vomiting. Although there are only a small number of retrospective studies of lacosamide in brain tumor patients with seizure, the results are promising. Lacosamide is an excellence choice as an add-on agent for brain-tumor patients with epilepsy resistant to one or more first line AEDs.