The aim of this study is to classify neonatal seizures using seizure semiology and identifying the underlying causes and the immediate outcome of seizures among neonates admitted in NICU- Khartoum-Sudan. The study included all neonates with seizure admitted to NICU at three main hospitals in Khartoum-Sudan. One hundred and sixteen neonates were enrolled in the study. Data was collected using designed questionnaire with emphasis on history, physical examination, investigations, management and outcome of seizure. Out of 1500 neonates admitted to NICU in the study area 116(7.7%) had seizures as a major presenting symptoms. Forty eight neonates (41.4%) had hypoxic ischemic encephalopathy, Twenty six (22.4%) had evidence of septicemia/ meningitis and primary biochemical abnormalities accounted for 32(27.6%). The most common seizure type was generalized tonic clonic in 51 (44%) followed by 30(25.9%) had focal clonic. Eighty nine (76.7%) neonates were well controlled , 26(22.4%) were partially controlled and one (0.9%) neonates had poorly controlled seizures .Neonates whose mothers had illnesses related to pregnancy , neonates with generalized seizures, preterm delivery, seizures started in the first 24 hours of life and neonates with abnormal brain image, had poorly controlled seizures. Facilities for Neonatal resuscitation, prevention of Birth Asphyxia and safe deliveries are mandatory at all levels of health care systems.