Aim: To explore the relation between left atrial pressure (LAP) and volume (LAV) in ischemic stroke patients with or without atrial fibrillation (AF). We hypothesized that there is an association between high LAP and atrial fibrillation. Methods: All patients admitted to the Stroke unit, Haukeland University hospital are registered in the Norstroke database. A subgroup of the patients was referred to an out clinic cardiologist for transthoracic echocardiography based on the judgments by the clinician in charge of the patients during the hospital stay. The transthoracic echocardiography included measurement of LAV, LAP and ejection fraction (EF). Risk factors and MRI findings were registered. Univar ate, multivariate and lowess smoother curve analyses were performed. Results: In total, 138 patients were referred to the cardiologist and 23 (17%) had documented AF. Linear regression analysis showed that LAP was independently associated female sex, hypertension and increasing LAV (all P<0.05). Linear regression analysis showed that LAV was independently associated with male sex, AF and increasing LAP (all P<.05). Lowess smoother curves showed U-shaped relations between LAV and both AF and old cerebral infarction on MRI. Conclusion: We did not find an association between LAP and AF even though LAP correlated with LAV. However, we found U-shaped relations between LAV and both AF and old cerebral infarction on MRI.