Salivary Alpha-Synuclein to Differentiate Parkinson’s Disease from Drug Induced Parkinsonism and Controls Using ELISA - Abstract
Background: Alpha-synuclein is a promising biomarker for Parkinson’s disease (PD). Objectives: To test the diagnostic accuracy of salivary alpha-synuclein concentration to distinguish PD from drug-induced parkinsonism (DIP) and controls. Methods: Between March 2017 and February 2020, total and oligomeric alpha-synuclein concentration were measured in 31 PD and 26 DIP patients and 20 age- and sex-matched controls. Diagnoses of PD and DIP were based on DAT-SPECT results. Salivary oligomeric alpha-synuclein concentration was assessed by ELISA and total alpha-synuclein concentration by electrochemiluminescence-ELISA. Results: Salivary oligomeric alpha-synuclein concentration was undetectable in the three groups and total alpha-synuclein concentration was not different between groups (p=0.350). Conclusion: Quantification of salivary alpha-synuclein with ELISA does not seem to be accurate to distinguish PD from DIP and controls.