Variation of the REDOX Status in Patients with Primary Autism after Antioxidant Therapy - Abstract
Oxidative stress plays an important role in the pathophysiology of autism. This research was carried out to know if the indicators of oxidative stress improved after a diet and antioxidant treatment in patients with primary autism. We studied 40 cases with primary autism treated at the Clinical Genetics National Reference Service in Juan Manuel Márquez Pediatric Hospital and Mayabeque Neurodevelopment Consultation during October 2014 to June 2016. Markers of oxidative damage and antioxidant defense were determined. Patients with altered oxidative stress were treated with diet and antioxidant therapy and the response to treatment was re-evaluated over time. A high percentage of patients improved the results of protein oxidation products (p <0,001), and total peroxide values post-therapy. However malonylaldehyde results remained elevate after treatment. No significant results were found for the antioxidant defense markers. The results of this research suggest that the use of antioxidant therapy associated with the established diet would be adequate.