Background: khat chewing has been practiced from ancient by people in the Eastern part of Africa, the Arabian, Peninsula and other parts of the world. In Ethiopia, khat chewing is becoming habitual and the proportion of people chewing khat has significantly risen over the years and chewers’ population in Ethiopia is now 16% from the country’s population. The main aim of this study was to provide national data on life time prevalence of khat chewing and associated factors that will serve as evidence for policy and planning and as baseline data for further studies. Methods: The data for this study was extracted from the 2016 EDHS. The 2016 EDHS is the fourth and most recent in the Demographic and Health Survey series in Ethiopia. Socio demographic variables were selected based on their availability in the dataset Our analysis included all men and women age 15-49 years which resulted in a total weighted sample of 27,289 Descriptive statistics were employed to show the distribution of socio-demographic characteristics Logistic regression model was used to determine the true association between chat chewing and basic socio-demographic factors Results: Of the total sample of 27289 of men and women age 15-49 years at the time of survey, 18.3% (n = 5006) have life time that chewing in Ethiopia, About 71.7% of the variation in the outcome variable (that chewing) is explained by the independent variables included in model Men and women in the 15-19 age group 9.952 (AOR9.952 95% CI 6.156- 16.091) and Men and women age 15-49 years in urban areas 34.040 (AOR 34.040; 95% CI: 21.028--55.105) were found to be major contributing factors to the that chewing. Conclusions: Younger age and urban residence had a statistically significant association with that chewing. Therefore, to effectively control khat chewing in Ethiopia, Creating awareness and increasing knowledge on the harmful effects of that chewing are recommended. A particular attention should be given to young adolescent and urban areas