Clozapine is a unique antipsychotic with demonstrated efficacy for treatment-resistant schizophrenia and mania, and aggression, suicide, or psychogenic polydipsia related to schizophrenia. Sialorrhea, a common adverse effect, is often a barrier to clozapine treatment. Anticholinergic agents have limited efficacy and carry elevated risks of constipation, bowel impaction, or ileus. Periodic injection of major salivary glands with botulinum neurotoxin has proven to be a superior treatment option for clozapine-induced sialorrhea (CIS). This mini-review describes the viability and logistics involved in establishing a successful botulinum treatment clinic in a forensic psychiatric hospital, including adequate administrative support and nursing staff, clinician training, educating treatment providers about the availability and effectiveness of botulinum treatment for sialorrhea, and development of a clinic protocol (e.g., procedural elements and relevant rating scales). Finally, botulinum treatment was evaluated to be cost-effective.