Recent Findings: Despite endoscopic sinus surgery (ESS) being the standard treatment for Chronic rhinosinusitis with nasal polyps (CRSwNP), a high recurrence rate and remaining olfactory complaints often characterize the postoperative period in eosinophilic nasal polyp disease. Reboot surgery was proposed for patients with recurrent and severe CRSwNP, evtl. complicated by asthma comorbidity, to answer to these shortcomings. Purpose of Review: The purpose of this review was to summarize the current literature on the indication of non-mucosa sparing Reboot surgery for patients with eosinophilic (Type-2) severe uncontrolled Chronic rhinosinusitis with nasal polyps (eCRSwNP), especially when former surgery failed, providing long-term sense of smell and polyp-free status. Summary: The extent of the surgery in CRS generally depends on the extension and severity of the disease, but also should be guided by the type of sinus inflammation. Reboot surgery has been developed to remove the mucosal memory of triggers leading to the modulation of healthy mucosa into Type-2 eosinophilic disease and allow the growth of a functional respiratory epithelium covering the sinuses. Questions about the microstructure and function of the mucosa after reboot surgery remained unsolved initially; however, long-term follow-up studies of patients with electron microscopical evaluations answer these questions today and are summarized in this review. Further, we aimed to describe the current understanding of indications for Reboot surgery and post-operative long-term results.