AbstractIt is well recognized that an imbalance of intracellular Ca2+ homeostasis contributes to the pathogenesis of neurodegenerative diseases, such as Alzheimer’s (AD). Therefore, regulation of intracellular Ca2+ homeostasis may represent a new target fo.....
AbstractObjectives: This study aims to demonstrate the effectiveness of progressive music activation to improve selective attention in patients diagnosed with
Alzheimer’s disease (AD) and healthy older adults.
Methods: 58 residents of senior centers or .....
AbstractEndoplasmic reticulum (ER), a multifunctional organelle, plays an important role in the maintenance of intracellular calcium homeostasis and regulation of cell death. Cellular stress conditions such as glucose deprivation, depletion of ER calcium sto.....
AbstractObjective: Traditional Cognitive Training with paper-pencil tasks (PPCT) and Computer-Based Cognitive Training (C-BCT) both are effective for people with Mild Cognitive Impairment (MCI). The aim of this study is to evaluate the efficacy of a C-BCT pr.....
AbstractCumulative evidence shows that innate immunity participates in the pathogenesis of Alzheimer´s disease. This implies that activation of microglia by the so called “damaged signals” triggers a cascade of pathological molecular events thus leading.....