Introduction: The combination of hypertension (HTN) and diabetes mellitus is common and significantly increases the risk of cardiovascular, renal, and cerebrovascular disease. The objective of this study was to describe the epidemiological, clinical, therapeutic, and long-term aspects of the association between Hypertension and diabetes among patients admitted to the Sino-Guinean Friendship Hospital. Methodology: This was a descriptive cross-sectional study conducted over a 6-month period from December 13, 2022, to June 13, 2023. The study included all patients seen in outpatient consultations at the cardiology department and the emergency department of the Sino-Guinean Friendship Hospital. Results: Out of a total of 5,068 patients seen, 132 patients had a combination of diabetes and hypertension (2.6% of consultations). The 61–67 age group was the most represented (26.5%), with a predominance of housewives (30.0%). Patient care was provided in the cardiology department (36.4% of cases). Palpitations (18.0%), followed by polydipsia (17.0%) and polyuria (16.0%), were the main reasons for consultation. Strokes were the most frequent complications (14.0%), followed by renal failure (12.0%). The outcome was favorable in 60.6% of patients, indicating a good response to treatment and effective management Conclusion: The combination of hypertension and diabetes primarily affects middle-aged individuals, with a predominance of type 2 diabetes and severe complications such as stroke and kidney failure.