AbstractIt is widely stated that treatment of human cells with
genotoxic agents either results in activation of cell cycle
checkpoints to facilitate DNA repair and promote cell survival, or
leads to apoptosis or other modes of cell death (e.g., necrosi.....
AbstractCancer has been a great dilemma to the medical sectors worldwide since the mortality rate is higher than its survival rate. The abruptly increasing mortality rate of cancer includes it among the top leading causes of demise worldwide. The presence o.....
AbstractCell death is defined by different factors ranging from default in functional properties, changes in morphological appearance and loss in immunological characteristics among so many others. These are brought about by accidental and programmed proce.....
AbstractIntroduction: With a population of over 180 million, Nigeria has only seven radiotherapy centers, four of which have a Linear Accelerator, while the remaining three use Cobalt 60. It is quite unfortunate that most of these centers still embrace manu.....
AbstractGermline testing for clinical cancer care and risk assessment
is commonly employed as approximately 10% of all cancers are
thought to have a heritable component [1]. Due to the genetic
heterogeneity of inherited cancer risk factors, current tes.....
AbstractCancer is a public health problem worldwide affecting all ages. It is the second commonest cause of death in developed countries and among the three leading causes of death in developing countries. WHO reported that about 24.6 million people live wi.....
AbstractThis study models some risk factors for some topographies of cancer in South West of Nigeria (Osun, Ondo, Ogun, Ekiti, Oyo and Lagos states). Data on various topographies of cancer are collected by transcription from cancer registry and patients’ .....
AbstractDevelopment of anti-cancer targeted therapy remains of
the biggest challenges in the effective cancer treatment. In
addition to surgery and chemotherapy, ionizing radiation (IR)
is one of the most commonly employed treatment method for
many t.....
AbstractChimeric antigen receptor T cells (CARs) are a form of cellular immunotherapy whereby a patient’s T cells are re-engineered to express a chimeric tumor antigen-specific T cell receptor, leading to activation and expansion upon recognition of targ.....
AbstractObjectives: Authors aimed to investigate the association between GSTT1 and GSTM1 genetic polymorphism and susceptibility to acute myeloid leukemia (AML).
Materials and methods: Genotyping polymorphisms were studied in a total adult 178 individuals.....
AbstractContext: Uraria lagopodies DC. (Fabaceae) is currently used as a traditional medicinal plant in many small communities of Bangladesh, India, Africa and other countries in the world.
Objective: This text offers a review on U. lagopodies.
Methods:.....
AbstractOsteopontin (OPN) is a protein associated with several cellular processes, including development, carcinogenesis, and adhesion. The U87 and U251 glioblastoma multiforme cell line is a model for fast-growing malignant tumors. Taking advantage of th.....
AbstractBackground: Recently, HMG-CoA reductase inhibitors are receiving larger importance in cancer therapeutics as they targets both metabolic and signal transduction platform. However, their functional role in targeting Triple negative breast cancer cell.....
AbstractLung adenocarcinoma is one of the most commonly occurring cancer types and it is the leading cause of cancer-related deaths worldwide. Vanadium compounds have different pharmacological effects and have cytotoxic properties. Aim of this study was by .....
AbstractRAS oncogenes are master regulators of cancers. Somatic mutation in KRAS, HRAS and NRAS genes account for approximately 30% of human cancers. KRAS is the most frequently mutated isoform in RAS-driven cancers. Brain cancers are RAS-driven cancers de.....
AbstractLaser is a monochromatic, coherent, tunable light source available in different wavelength, mode and power. Laser is used in diagnosis and therapeutics in medicine. Photonanotherapy (PNT) is an emerging cancer treatment methodology involves the co.....
AbstractBackground: Breast Magnetic Resonance Imaging (MRI) follows - up is recommended in women at high risk (either genetic risk or family history) of breast cancer. However, its use is not extended in the case of patients with personal history of breast .....
AbstractBackground: Intraoperative cytology is supportive and diagnostic of glial lesions. This is due to the dyscohesive nature of glial lesions and lack of dense connective tissue. We have tried to assess the utility of smear technique in rapid diagnosis.....