Long Term Impact of Primary Graft Dysfunction after Lung Transplantation - Abstract
Primary graft dysfunction (PGD) is a common early complication after lung transplantation and represents an acute lung injury with clinical, radiographic, and histological features similar to acute respiratory distress syndrome (ARDS). PGD is associated with prolonged mechanical ventilation, longer intensive care unit and hospital stays, and increased short-term mortality. Importantly, recipients who develop severe PGD are at increased risk of long-term mortality and may have worse functional status and lower peak lung function. In addition, all grades of PGD are associated with an increased risk of chronic rejection. Multiple donor and recipient factors have been linked with the development of PGD, and therapy consists primarily of supportive care similar to patients with ARDS.