The Amazing Multi-Valency of the Hsp70 Chaperones - Abstract
Hsp70 proteins are keys to maintaining intra-cellular protein homeostasis. To carry out this task, they employ a large number of co-chaperones and adapter proteins. Here we review what is known about the interaction between the chaperones and partners, with a strong slant towards structural biology. Hsp70s in general and Hsc70 (HSPA8) in particular, display an amazing array of interfaces with their protein co-factors. We also reviewed the known interactions between Hsp70s and active compounds that may become leads towards Hsp70 modulation for treatment of a variety of diseases.