Numerous factors such as environmental, physiological, and genetic factors have a deep association with mast cells. These cells not only govern the immune response but also enhanced the defense mechanism naturally and prepared a host defense system. These cells recognized pathogens via the involvement of adhesion and immune receptors. Mast cells can act as inflammatory cells and their role in allergic disease, autoimmunity, propagation of diseases, and exacerbation of various types of diseases explored. These cells promote the recruitment of neutrophils in the location of autoimmune destruction at the time of origin of diseases. Mast cells displayed a potential role in various biological routes and processes such as the secretion of cytokines, release enzymes, acquiring immunity against parasitic infections, in the process of fibrosis, allergy, inflammation, and the pathology of autoimmune diseases.