Toxic Effect of Single Treatment with Kappa-Opioid Agonist, Ru-1205 Compound, on the Neurological Status of Wild Type Mice - Abstract
Using primary observation setting (includes open field, rota-rod, actometer, visual detection of tremor, convulsions, pyloerrection, Streub’s symptom, salivation, reflexes, ambivalence, vocalization and passivity) we investigated the neurotoxicological properties of novel kappa-opioid agonist RU-1205 in comparison with butorphanol for the presence of serious neurologic adverse reactions and matched the toxic doses with the analgesic ones. We revealed that the analgesic effect of RU-1205 persists over a wide range of doses (0.001-100 mg/kg) with maximum at 1 mg/kg and ED50 0.02 mg/kg (mice, hot-plate, and 55°C). In contrast, the ED50 of butorphanol is 0.2 mg/kg in the same conditions. The serious neurological disruptions after treatment with RU-1205 and butorphanol were observed at 50-100 mg/kg, but paying attention the 10 times greater analgesic efficiency of RU-1205. We concluded that RU-1205 is safer than butorphanol.