ATP-Binding Cassette Cholesterol Transporter Family and Hyperlipidemia - Abstract
Genetic characteristics of the individuals lead to the continuation of normal functions of the body by realizing their effects on metabolic pathways. Amino acid changes that occur on the structures of the genes effective on lipid metabolism (genetic polymorphisms) also change the functions performed by gene. As a result of this change, apolipoproteins in proteins related to lipoprotein metabolism often affect the changes in receptors, enzymes, or cofactors. Such changes occurring in connection with genetic changes are classified as primary disorders of the lipid mechanism. Changes occurring in ATP-Binding Cassette Cholesterol Transporter (ABCA1) gene may play an important role amongst these changes.