Recent Articles
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August 02, 2023 Case Report
Abstract Abstract The human Insulin Receptor (INSR) mutation can result in inherited insulin resistance syndrome. Severe Insulin Resistance (IR) results secondary INSR mutations have been reported in adult, adolescent and children manifesting with Hyperinsu.....
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February 07, 2023 Research Article
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February 15, 2019 Case Report
Abstract Type 2 Diabetes [T2D] incidence rate is increasing alarmingly among Bangladeshi population. A very few data are available in Bangladesh for T2D disease. The main objectives of this study were to estimate significant risk factors of diabetes mellitus .....
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May 26, 2014 Research Article
Abstract Soya (Glycine max (L) Merr) isoflavones have the property to enhance mitochondrial biogenesis and improve the status of diabetes mellitus. Isoflavones rich soya seed extract (DRE) was standardized for daidzin using HPLC. In the present investigat.....
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July 19, 2014 Review Article
Abstract It has been known for a long time that thyroid hormone regulates metabolism. Thyroid hormone action is primarily mediated by Thyroid Hormone Receptors (TRs). The transcriptional regulation by TRs is modulated by coregulators including coactivator.....
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July 19, 2014 Mini Review
Abstract Adipose tissue composed predominantly of adipocytes (differentiated fat cells) serves as a lipid storage and endocrine organ. It plays a major role in lipid metabolism and glucose homeostasis. Thyroid hormones have been known for years to play a .....
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July 19, 2014 Review Article
Abstract The amount of energy in the body is highly regulated. The hypothalamus is a key neural structure involved in this process, keeping the intake of food in step with the energy expenditure. The main hypothalamic nuclei involved in energetic metaboli.....
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July 19, 2014 Review Article
Abstract Thyroid Hormone (TH) regulates energy balance, lipid metabolism and cardiovascular function. These effects are largely due direct action of TH on peripheral target tissues. However, there is increasing evidence for a direct central action of TH modul.....
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July 19, 2014 Review Article
Abstract Skeletal muscle is a plastic organ made by highly specialize fibers with specific and different structure, function and metabolism. Skeletal muscle fibers can adapt, change, recover/regenerate after injury in response to various stimulators including.....
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July 19, 2014 Review Article
Abstract Thyroid hormone, acting through thyroid hormone receptors is a key regulator of metabolic homeostasis. Repression of transcription is critical component of thyroid hormone signaling and is mediated through the association of corepressor proteins with.....
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July 19, 2014 Mini Review
Abstract A gradually expanding body of literature suggests that Thyroid Hormone (TH) and Thyroid Hormone Receptors (TRs) play a contributing role in pancreatic and islet cell development, maturation, and function. Studies using a variety of model systems capa.....
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July 19, 2014 Review Article
Abstract Thyroid hormone plays an important role in the regulation of lipid metabolism. It acts predominantly through its nuclear receptors (thyroid hormone receptor ? and ?) to regulate the gene expression related to lipid metabolism. Both overt hypothyroidi.....
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July 19, 2014 Review Article
Abstract Thyroid hormones are central regulators of lipid metabolism and energy homeostasis, which primarily act through Thyroid Hormone Receptors (TRs). Selective Thyroid Hormone Receptor Modulators (STRMs) are chemical analogues of thyroid hormone, designed.....
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May 28, 2014 Research Article
Abstract Epidemiologic studies suggest that cardiovascular disease affects men at an earlier age and may contribute to greater mortality. Cross sectional and prospective studies have considered the role of endogenous testosterone levels in cardiovascular dise.....
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May 30, 2014 Review Article
Abstract Hypogonadism is frequently associated with metabolic syndrome and testosterone levels correlate with parameters which are part of the cluster defining the syndrome itself. Different studies suggest a positive role of testosterone replacement therapy,.....
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May 28, 2014 Review Article
Abstract Reproductive health is an important domain of women’s health care and broadly encompasses conditions which impact fertility, conception or birth of a healthy infant. Although numerous factors or conditions are associated with infertility, polycysti.....
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May 28, 2014 Mini Review
Abstract About 10% of European couples are suffering infertility problems. The underlying cause is evenly distributed. In the female polycystic ovaries, often associated with anovulatory cycles, contribute to a high extend of underlying problems. Despite the .....
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May 28, 2014 Review Article
Abstract Dimethylbiguanide (Metformin) is an anti-hyperglycemic drug used in the management of insulin resistance-related diseases like type 2 diabetes mellitus for over 40 years. The molecular mechanisms of action related to its metabolic effects are linked .....
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May 28, 2014 Review Article
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May 25, 2014 Review Article
Abstract Polycystic Ovary Syndrome (PCOS) is characterized by ovulatory disturbances, hyperandrogenaemia and hyperinsulinemia secondary to increased insulin resistance. In PCOS, hyperinsulinemic insulin resistance is of interest because skeletal muscle may be.....
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May 28, 2014 Research Article
Abstract Metformin is currently considered a first line therapy for managing type-2 diabetes for targeting insulin resistance and obesity. However, in usual busy clinical practice, the importance of metformin is sometimes ignored and patients are prescribed d.....
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May 24, 2014 Research Article
Abstract In Type 2 Diabetes Mellitus, incretin axes play an important role in terms of progressive beta abnormalities. It was found that enteroendocrin cells in the small bowel have T1R2 and T1R3 taste receptors. Artificial sweeteners and glucose have signifi.....
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May 28, 2014 Research Article
Abstract Objective: To determine whether the protective effect of metformin against death is modified by frailty status in older adults with type 2 diabetes. Research Design and Methods: We conducted a cohort study during October 1, 1999 September 30, 2006 .....
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May 29, 2014 Review Article
Abstract Metformin as the first line therapy for type 2 diabetes mellitus has its unique attraction for its weight loss and possible macrovascular benefit. In addition, recent accumulating epidemiological and clinical evidence suggests metformin maybe a poten.....
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May 28, 2014 Review Article
Abstract Recent progress in molecular medicine has identified the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1) as the central regulator of protein and lipid synthesis, cell growth, proliferation, energy metabolism and autophagy.....
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May 03, 2014 Review Article
Abstract Congenital hypothyroidism (CH) is the most frequent endocrine disorder in neonates. While several genetic mutations have been identified that result in developmental defects of the thyroid gland or thyroid hormone synthesis, genetic factors have yet .....
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May 08, 2014 Research Article
Abstract We sought to explore whether the adherence to the Mediterranean dietary pattern is associated with better plasma lipid profile, regardless of obesity, insulin resistance and metabolic syndrome. Adult outpatients free of clinical cardiovascular disea.....
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May 03, 2014 Research Article
Abstract Bone loss in patients with prostate cancer undergoing anti-androgen therapy is underestimated by physicians. Osteoporosis is a silent condition that can lead to major fracture events. The osteoporosis’s fractures has as consequence a decrease in a .....
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December 24, 2013 Research Article
Abstract Testosterone deficiency syndrome (TDS) is a clinical and biochemical syndrome frequently associated with age and co-morbidities and is characterized by deficiency in testosterone and relevant androgen-deficiency symptoms. The main physiological actio.....
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October 26, 2013 Review Article
Abstract Genetic characteristics of the individuals lead to the continuation of normal functions of the body by realizing their effects on metabolic pathways. Amino acid changes that occur on the structures of the genes effective on lipid metabolism (genetic .....
