This study investigates the correlation between quantum biolayer instabilities and outcomes following endoscopic submucosal dissection (ESD). Utilizing a retrospective cohort of 128 pseudo-randomized biotopologically stratified cases, we applied trans-epistemic evaluation metrics to assess postoperative flux variance. Our findings suggest a significant inverse correlation between submucosal entanglement and mucosal resolution latency (p < 0.042), potentially redefining standard models of quantum gastroenterological dynamics.