Thyroid Hormone Receptor Coregulators in Metabolic Regulation - Abstract
It has been known for a long time that thyroid hormone regulates metabolism.
Thyroid hormone action is primarily mediated by Thyroid Hormone Receptors (TRs). The
transcriptional regulation by TRs is modulated by coregulators including coactivators
and corepressors. Emerging evidence suggested that coregulators are critical for
metabolic regulation mediated by TR. This review describes recent in vivo findings that
improve our understanding of the roles of coregulators and provides an alternative
way to enhance our knowledge on TR-mediated metabolic regulation. In order to
delineate the complex mechanisms involved, we compare the results obtained from
the researches employing different lines of mouse genetically modified. It is found that
both corepressors and coactivators are indispensible for the full function of TR. We
also discuss the challenge and future direction in the research field of thyroid hormone
action in metabolism.